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肖立华

肖立华教授,博士生导师

 学科:预防兽医学                                      
邮箱地址:lxiao@scau.edu.cn
通讯地址: 广东省广州市天河区五山路483号
简介


特聘教授,美国寄生虫学会杰出贡献奖“Henry Baldwin Ward Medal”获得者,2018-2022年4次入选Web of Science的全球高被引科学家。1990年获美国缅因大学博士学位。1991至1993年在美国俄亥俄州立大学从事博士后研究。1993至2017年在美国疾病预防控制中心工作,先后任副研究员和研究员。2018年全职回国工作。现任Clin Microbiol Rev(IF=20.6)、Front Microbiol Microbiol(IF=4.3)和Parasitol Res1 Res(IF=2.1)的副主编,以及J Clin Microbiol、Appl Environ Microbiol、Vet Parasitol和Exp Parasitol等6个SCI期刊的编委。主要从事人兽共患寄生虫病的病原生物学、检测和溯源研究。

学术贡献如下:(1)建立了隐孢子虫属的虫种命名标准,命名了人和家畜的8个常见虫种,改写了该属只包含1个广宿主虫种的历史;(2)发现大多数虫种具有宿主适应性,即每个虫种只感染一些特定宿主,且感染人的常见虫种只有5个;(3)进一步建立了集溯源和致病风险评估于一体的方法,成为International Water Association的标准方法;(4)建立了虫种区分和亚型鉴定工具,成为疾病暴发调查的首选方法,发现了引起暴发的高毒力亚型,创建了世界上唯一的寄生虫病主动监测网络系统CryptoNet;(5)解析了隐孢子虫病在发展中国家传播的独特性,揭示了隐孢子虫宿主适应性和毒力的遗传决定因素,并筛选了潜在的药物和疫苗靶标。以上工作有助隐孢子虫的动物源头防控,保障人体和水质安全,减少隐孢子虫病暴发。发表SCI论文500篇,被引30000次,H指数90,是隐孢子虫领域论文被引次数最高的作者,也是贾第虫、毕氏肠微孢子虫和环孢子虫研究领域排名前几名的作者。其他科学家以肖立华的名字命名了一个隐孢子虫虫种(Cryptosporidium xiaoi),以肯定他对隐孢子虫领域的贡献。主编CRC Press出版的英文专著《Cryptosporidium and Cryptosporidiosis》和《Biology of Foodborne Parasites》。



工作经历


1985-1987:讲师,东北农业大学

1991-1992:博士后,美国俄亥俄州立大学

1993-2017:副研究员/研究员,美国疾病预防控制中心

2018-至今:特聘教授,华南农业大学


教育经历


1978-1982:学士,湖南农业大学,兽医学专业

1982-1985:硕士,中国农业大学,兽医寄生虫学专业

1987-1990:博士,美国缅因大学,寄生虫学专业


获奖荣誉


2018-2022:Highly Cited Researchers,Web of Science(全球高被引学者4次)

2018:Excellence in Laboratory Research,National Center for Emergening and Zoonotic Infectious Diseases,CDC,Atlanta,USA

2004:Unit Citation Award,National Oceanic Atmospheric Administration

2008:CDC Public Health Epidemiology and Laboratory Research Award,Atlanta,USA

2008:NCZVED/CDC Laboratory Science Mentorship Award, Atlanta,USA

2010:Top Cited Article 2008-2010,International Journal for Parasitology, Elsevier

2011:Outstanding Service,American Society for Microbiology Minority Mentoring Program,USA.

2012: Top Cited Article 2009-2011,Experimental Parasitology, Elsevier

2012:美国寄生虫学会杰出成就奖“Henry Baldwin Ward Medal”


社会、学会及学术兼职


2018-至今:Frontiers in Microbiology副主编

2017-至今:Parasitology Research副主编

2014-2020:Clinical Microbiology Reviews副主编

2019-至今:One Health编委

2018-至今:Veterinary Parasitology编委

2017-至今:Food and Waterborne Parasitology编委

2010-至今:Clinical Microbiology Reviews编委

2014-2019:Journal of Clinical Microbiology编委

2010-2019: Applied and Environmental Microbiology编委

2012-至今:Experimental Parasitology编委

2007-至今:The Open Journal of Parasitology编委

2009:Experimental Parasitology,Special issue特邀编辑

2009-至今:CryptoDB、MicrobeNet、NIH-CDC-HIVMA/IDSA、USEPA SAM Pathogen Methods咨询委员会委员


研究领域


以食源性和水源性病原体(如隐孢子虫、贾第虫、环孢子虫和微孢子虫等)为研究对象,长期从事其病原生物学、分子检测和溯源及生态学研究。主要研究方向包括:

1.食源性、水源性新发病原的生物学、遗传学、分子流行病学和生态学

2.食源性、水源性新发病原的侵入、跨种传播及致病机理

3.食源性、水源性新发病原的比较和功能基因组学及其应用


发表论文


1.Xiao, K., Zhai, J., Feng, Y., Zhou, N., Zhang, X., Zou, J.J., Li, N., Guo, Y., Li, X., Shen, X., Zhang, Z., Shu, F., Huang, W., Li, Y., Zhang, Z., Chen, R.A., Wu, Y.J., Peng, S.M., Huang, M., Xie, W.J., Cai, Q.H., Hou, F.H., Chen, W.*, Xiao, L.*, Shen, Y.*, 2020.Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins. Nature 583, 286-289.

2.Feng Y., Ryan U.M., Xiao L.*, 2018.Genetic diversity and population structure of Cryptosporidium. Trends in parasitology 34, 997-1011.

3.Feng Y.* and Xiao L.*, 2017.Molecular epidemiology of cryptosporidiosis in China. Frontiers in Microbiology 8:1701.

4.Zhang, Q., Guo, Y., Li, N., Li, Y., Su, J., Xu, R., Zhang, Z., Feng, Y.*, Xiao, L.*, 2020.Characterization of Calcium-dependent protein kinases 3,  a protein involved in growth of Cryptosporidium parvum.Frontiers in Microbiology 11, 907.

5.Xu, R., Guo, Y., Li, N., Zhang, Q., Wu, H., Ryan, U., Feng, Y.*, Xiao, L.*, 2019.Characterization of INS-15,  A metalloprotease potentially involved in the invasion of Cryptosporidium parvum.Microorganisms 7.

6.Zhang, S., Chen, L., Li, F., Li, N., Feng, Y.*, Xiao, L.*, 2019.Divergent copies of a Cryptosporidium parvum-specific subtelomeric gene.Microorganisms 7.Su, J., Jin, C., Wu, H., Fei, J., Li, N., Guo, Y., Feng, Y.*, Xiao, L.*, 2019.Differential expression of three Cryptosporidium species-specific MEDLE proteins.Frontiers in Microbiology 10, 1177.

8.Li, N., Wang, R., Cai, M., Jiang, W., Feng, Y.*, Xiao, L.*, 2019.Outbreak  of cryptosporidiosis due to Cryptosporidium parvum subtype IIdA19G1 in neonatal calves on a dairy farm in China.International Journal for Parasitology 47, 569-577.

9.Xu, Z., Guo, Y., Roellig, D.M., Feng, Y.*, Xiao, L.*, 2019.Comparative analysis reveals conservation in genome organization among intestinal Cryptosporidium species and sequence divergence inpotential secreted pathogenesis determinants among major human-infecting species. BMC Genomics 20, 406.

10.Zhang, S., Wang, Y., Wu, H., Li, N., Jiang, J., Guo, Y., Feng, Y.*, Xiao, L.*, 2019.Characterization of a species-specific insulinase-like protease in Cryptosporidium parvum.Frontiers in Microbiology10, 354.

11.Wang, Y., Li, N., Guo, Y., Wang, L., Wang, R., Feng, Y.*, Xiao, L.*, 2018.Persistent Occurrence of Cryptosporidium hominis and Giardia duodenalis Subtypes in a Welfare Institute.Frontiers inmicrobiology 9, 2830.

12.Feng, Y., Gong, X., Zhu, K., Li, N., Yu, Z., Guo, Y., Weng, Y., Kvac, M., Feng, Y.*, Xiao, L.*, 2019.Prevalence and genotypic identification of Cryptosporidium spp.,  Giardia duodenalis andEnterocytozoon bieneusi in pre-weaned dairy calves in Guangdong, China.Parasites & Vectors 12, 41.

13.Liu S., Roellig D.M., Guo Y., Li N., Frace M.A., Tang K., Zhang L.,  Feng Y.*and Xiao L.*(2016)Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium.BMCGenomics, 17:1006.

14.Liu S., Wang L., Zheng H., Xu Z., Roellig D.M., Li N., Frace M.A., Tang K., Arrowood M.J., Moss D.M., Zhang L., Feng Y.*, and Xiao L.*(2016) Comparative genomics reveals Cyclosporacayetanensis possesses coccidia-like metabolism and invasion components but unique surface antigens. BMC Genomics 17, 316.

15.Li P., Cai J., Cai M., Wu W., Li C., Lei M., Xu H., Feng L., Ma J., Feng Y.*, and Xiao L.*(2016)Distribution of Cryptosporidium species in Tibetan sheep and yaks in Qinghai, China.Veterinary Parasitology 215, 58-62.



专著教材


1.Xiao L.,Ryan U.,and Feng Y.(eds)(2015)Biology of Foodborne Parasites.CRC Press,Boca Raton,FL,507 pages.

2.Ryan U.,Power M.,and Xiao L.(eds)(2010) Cryptosporidium and Other Waterborne Protozoa. Experimental Parasitology,Volume 124,Issue 1(Special Issue),146 pages.

3.Fayer R.and Xiao L.(eds)(2008)Cryptosporidium and Cryptosporidiosis,2nd edition,CRC Press and IWA Publishing,Boca Raton,FL,560 pages.

4.Xiao L.,Alderisio K., and Singh A. Development and Standardization of a Cryptosporidium Genotyping Tool for Water Samples.Awwa Research Foundation,Denver,Colorado,2006,116 pages.1P-3.5C-91101-03/06-CM.


教学活动


讲授《兽医寄生虫学(全英)》等课程。


指导学生


已毕业研究生博士研究生14名,硕士研究生20余名。目前指导在读博士研究生6名,硕士研究生12名。


我的团队


所带领的团队包括教授2名,副教授4名,博士后1名。


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